Activated Tumor Necrosis Factor (TNF) receptors with TNF bound and inactivated monomeric receptors

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SS22649644

Activated Tumor Necrosis Factor (TNF) receptors with TNF bound and inactivated monomeric receptors. Monomeric tumor necrosis factor receptors (light blue) get activated after binding TNF (dark blue) and build trimeric complexes. The lighter bottom domains are the death domains. TNF receptors are primarily involved in apoptosis and inflammation.

Juan Gaertner / Science Source

SS2CT84082_20200608